Contact
Lab
MR4 1111
409 Lane Rd, MR4 Building Room 1111
Charlottesville, VA 22904

Adrian Shimpi, Ph.D.

Postdoctoral Research Associate
Contact
Lab
MR4 1111
409 Lane Rd, MR4 Building Room 1111
Charlottesville, VA 22904
Google Scholar Naegle Lab

About

Dr. Adrian Shimpi is a biomedical engineer that focuses on understanding the molecular networks that contribute to cellular heterogeneity. As a member of Dr. Kristen Naegle’s lab, Adrian focuses on using data-driven and computational approaches to study the molecular networks associated with phosphotyrosine signaling. He integrates these computational methods with cellular and molecular engineering approaches to investigate how changes in cellular microenvironments alter the complex networks that regulate cell phenotypes. His goal is to understand and describe the molecular ecosystem available within different cell states and how they relate to diseased states.

Adrian received his Ph.D. from Cornell University under the mentorship of Dr. Claudia Fischbach-Teschl. During his Ph.D. he applied integrative approaches to understand the interplay of the extracellular matrix and cancer cell phenotype heterogeneity. During this time, he received the NSF Graduate Research Fellowship.

Education

PhD in Biomedical Engineering, Cornell University, 2023

BS in Bioengineering, University of Utah, 2016

Research Interests

Systems Biology
Cancer Biology
Phosphorylation
Cellular Heterogeneity
Cell-Extracellular Matrix Interactions

Selected Publications

Convergent approaches to delineate the metabolic regulation of tumor invasion by hyaluronic acid biosynthesis, Adv Healthc Mater. 2023 Jun;12(14):e2202224 ., Shimpi AA, Tan ML, Vilkhovoy M, Dai D, Roberts LM, Kuo JC, Huang L, Varner JD, Paszek M, Fischbach C.
Link
Phosphoproteomic Changes Induced by Cell-Derived Matrix and Their Effect on Tumor Cell Migration and Cytoskeleton Remodeling. ACS Biomaterials Science & Engineering. 2023 November; 9(12):6835-6848 . Shimpi A, Williams E, Ling L, Tamir T, White F, Fischbach C.
Link
Engineered ECM models: Opportunities to advance understanding of tumor heterogeneity. Curr Opin Cell Biol. 2021 Oct;72:1-9.
Shimpi AA, Fischbach C.
Link
Measuring and modelling tumour heterogeneity across scales. Nature Reviews Bioengineering. 2023 July; 1(10):712-730. Beeghly G, Shimpi A, Riter R, Fischbach C.
Link
Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer. Nat Biomed Eng. 2023 Nov;7(11):1455-1472. Choi S, Whitman MA, Shimpi AA, Sempertegui ND, Chiou AE, Druso JE, Verma A, Lux SC, Cheng Z, Paszek M, Elemento O, Estroff LA, Fischbach C.
Link

Awards

National Science Foundation Graduate Resaerch Fellowship Program